Initial clinical improvement with pergolide is expected within 6 to 12 weeks. Horses may respond clinically at lower or varying doses; it is therefore recommended to titrate to the lowest effective dose per individual based on response to therapy and endocrine testing.
How long does it take for Prascend to work?
It usually takes between 6-12 weeks to see a clinical benefit of treatment, although in some unusual cases it can sometimes take several years before a benefit is seen.
Does pergolide prevent laminitis?
Any potential benefits of pergolide on laminitis would depend on the circumstances of each patient and their pretreatment risk of laminitis but current evidence does not support the widespread use of pergolide to prevent laminitis.
How is pergolide given to horses?
Once equine PPID is diagnosed, pergolide can be administered at a rate of 2 μg/kg body weight daily. This medication functions by blocking dopamine receptors located in the hypothalamus to decrease the excessive production of hormones and other mediators.
Does pergolide cause diarrhea in horses?
Pergolide is FDA approved for use in horses and has been evaluated for safety. In field trials, decreased appetite occurred but was usually transient. Weight loss, anorexia, diarrhea, colic, lethargy, and behavioral changes have been observed in some horses. CNS effects may include ataxia and dyskinesia.
Can horses with Cushings eat carrots?
Unfortunately most commercially made horse treats, as well as apples and carrots, can be high in sugar. This presents a problem with horses that have Cushing’s disease, or Insulin Resistance/Metabolic Syndrome, as those horses’ sugar and starch intake must be limited.
Should I give my horse pergolide?
Pergolide is a prescription drug and should be used according to your veterinarian’s directions, and given only to the animal for which it was prescribed. Do not give this medication to a person. High doses of pergolide have been tested in laboratory animals without causing detectable harm to the fetus.
What does pergolide treat in horses?
Pergolide is a human drug used to treat Parkinson’s Disease. Pergolide is the drug of choice to treat pituitary pars intermedia hyperplasia or equine Cushing’s Syndrome (ECS) in horses. Pergolide works by binding with drug receptors in the brain that control the production of dopamine.